A mad scientist holds the world hostage with his terrifying inventions. An alien warlord from a far away galaxy brings his limitless army of bizarre minions to conquer the planet. A giant rampaging robot cuts a swath of destruction across the coast, destroying major population centers. And who will stand in their way? A team of heroes, all with impressive powers and abilities stand between the world and the forces of evil. Will you help them? Answer the call to protect the multiverse!

Sentinels of the Multiverse is a cooperative, fixed-deck card game with a comic book flavor. Each player plays as one of ten heroes, against one of four villains, and the battle takes place in one of four different dynamic environments.

Each player, after selecting one of the heroes, plays a deck of 40 cards against the villain and environment decks, which "play themselves", requiring the players to put the top card of the appropriate deck into play on the villain and environment turns. On each player's turn, they may play a card from their hand, use a power printed on one of their cards in play, and draw a card from their deck. Each round starts with the villain turn, continues clockwise around the table, then concludes with the environment turn. Each villain has various advantages, such as starting with certain cards in play, as specified by the villain character card. Play continues until the heroes reduce the villain to 0 or fewer HP, or until the villain defeats the heroes, either via a win condition or by reducing all the heroes to 0 or fewer HP.

Expansions:

• Rook City
• Infernal Relics
• Shattered Timelines
• Vengeance

Mini-Expansions:

• Ambuscade Villain Character
• Miss Information Villain Character
• Silver Gulch, 1883 Environment
• The Final Wasteland Environment
• The Scholar Hero Character
• Unity Hero Character

Core Game:
578 63mm by 88mm cards
- 10 Hero Character Cards
- 10 Hero Decks of 40 cards each
- 8 Villain Character and Game Text Cards
- 4 Villain Decks of 25 cards each
- 4 Environment Decks of 15 cards each

Regular Expansions:
Each regular expansion includes 2 additional heroes, 4 additional villains, and 2 additional environments.
Sentinels of the Multiverse: Rook City
Sentinels of the Multiverse: Infernal Relics
Sentinels of the Multiverse: Shattered Timelines

Mega Expansions:
Each mega expansion includes 5 additional heroes, 5 additional villains, and 2 additional environments.
Sentinels of the Multiverse: Vengeance (October 2013)

Mini Expansions:
Each mini expansion includes 1 additional deck.
Sentinels of the Multiverse: Unity Hero Character
Sentinels of the Multiverse: Ambuscade Villain Character
Sentinels of the Multiverse: Miss Information Villain Character
Sentinels of the Multiverse: Silver Gulch, 1883 Environment
Sentinels of the Multiverse: The Scholar Hero Character
Sentinels of the Multiverse: The Final Wasteland Environment

Promotional Cards:
Each promo card provides an alternate character card (2 for villains) to be played with the associated character deck found in the core game or expansions.
Sentinels of the Multiverse: Young Legacy Promo Card
Sentinels of the Multiverse: Rook City The Wraith Promo Card
Sentinels of the Multiverse: Vengeful Baron Blade Villain Promo Card
Sentinels of the Multiverse: Cosmic Omnitron Villain Promo Card
Sentinels of the Multiverse: Ra - Horus of Two Horizons Promo Card
Sentinels of the Multiverse: Redeemer Fanatic Promo Card
Sentinels of the Multiverse: Dark Visionary Promo Card
Sentinels of the Multiverse: Freedom Six Promo Pack
Sentinels of the Multiverse: The Eternal Haka Promo Card
Sentinels of the Multiverse: America's Greatest Legacy Promo Card (October 2013)

Microbadges:
Sentinels of the Multiverse - Fan
Sentinels of the Multiverse - Fan
Sentinels of the Multiverse - Fan
Sentinels of the Multiverse - Fan
Sentinels of the Multiverse - Citizen Dawn - Rise!